Henan Yufu New Materials Co.,Ltd
Halogenated chemical
CAS NO. 542-58-5
ACETIC ACID 2-CHLOROETHYL ESTER
Product Name | ACETIC ACID 2-CHLOROETHYL ESTER |
Synonyms | 2-CHLOROETHYL ACETATE;1-Acetoxy-2-chloroethane;2-Acetoxy-1-chloroethane;2-Acetoxyethyl chloride;2-Chlorethylacetat;2-chloro-ethanoacetate;2-Chloroethanol acetate;2-chloroethanolacetate |
CAS NO. | 542-58-5 |
Purity | 98%MIN |
Molecular formular | C4H7ClO2 |
Molecular weight | 122.55 |
EINECS | 208-820-2 |
Capacity | 5000MT anuual |
Package | 25KG drum |
Loading Port | Shanghai, Qingdao, Tianjin, Lianyungang, Guangzhou |
Shipment method | By Sea, Air,Courier door to door, etc |
Structure |
|
Application:
It can be used as pharmaceutical intermediate.
It can be used to prepare 3-keto-4-androstene-17 β The carboxylic acid comprises the following steps: 1) 3 β- Ethyl 2-chloroacetate was added slowly to 3,5-androstadien-17-one to give 3 β- Ethyl ether-3,5-androstadiene-17,20-epoxy-20-carboxylate; 2)3 β- Ethyl ether-3,5-androstadien-17,20-epoxy-20-carboxylate was decarboxylated at high temperature and hydrolyzed to give 3-keto-4-androstadien-20-aldehyde; 3) 3-keto-4-androsten-17 was synthesized by oxidation of 3-keto-4-androsten-20-aldehyde β Carboxylic acid. The method proposed in the invention changes the synthetic route and the starting synthetic raw material, and adopts the cheap 4AD derivative raw material 3 β- Diethyl ether-3,5-androstadien-17-one reduced the reaction steps and the reaction conditions were mild; The synthesis method proposed by the invention is more simple, economical and environmental friendly, and is convenient for industrial implementation.
